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Cardiovascular effectiveness of newer glucose-lowering agents, with and without baseline lipid-lowering therapy in type 2 diabetes: a systematic meta-analysis of cardiovascular outcome trials and real-world evidence

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[62] In a heart with AF, the increased calcium release from the sarcoplasmic reticulum and increased calcium sensitivity can lead to an accumulation of intracellular calcium and cause downregulation of L-type calcium channels

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