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(5.5) Because fluoroquinolones, including CIPRO, have been associated with serious adverse reactions (5.1-5.16), reserve CIPRO for use in patients who have no alternative treatment options for the following indications: Acute sinusitis (1.12) Recent Major Changes Warnings and Precautions, Hypersensitivity Reactions (5.7) 9/2024 Indications and Usage for Cipro CIPRO is a fluoroquinolone antibacterial indicated in adults (18 years of age and older) with the following infections caused by designated, susceptible bacteria and in pediatric patients where indicated: Skin and Skin Structure Infections (1.1) Bone and Joint Infections (1.2) Complicated Intra-Abdominal Infections (1.3) Infectious Diarrhea (1.4) Typhoid Fever (Enteric Fever) (1.5) Uncomplicated Cervical and Urethral Gonorrhea (1.6) Inhalational Anthrax post-exposure in adult and pediatric patients (1.7) Plague in adult and pediatric patients (1.8) Chronic Bacterial Prostatitis (1.9) Lower Respiratory Tract Infections (1.10) Acute Exacerbation of Chronic Bronchitis Urinary Tract Infections (1.11) Urinary Tract Infections (UTI) Acute Uncomplicated Cystitis Complicated UTI and Pyelonephritis in Pediatric Patients Acute Sinusitis (1.12) Usage To reduce the development of drug-resistant bacteria and maintain the effectiveness of CIPRO and other antibacterial drugs, CIPRO should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria