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At the simplest level, DNA methylation level at a single CpG site within AHRR (described by Illumina array probe ID cg05575921) has been shown to discriminate between adult non-smokers and current-smokers 6,7 , and former- from never-smokers 8 , while other multi-probe scores have also been developed to assess various phenotypes, ranging from exposure to maternal smoking 9,10,11 to smoking-related mortality 12

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