In the case of misuse (like taking a higher dosage than prescribed), your risks of severe side effects, addiction, overdose, and death increase dramatically
Sugahara H, Maebara C, Ohtani H, Handa M, Ando K, Mine K, et al
Major Risk Factors Cholesterol and Heart Disease Risk Ways to Lower Your Cholesterol Weight and Heart Disease Diabetes and Heart Disease What Else Affects Heart Disease Risk Factors Specific to Women Taking Charge: An Action Plan for Heart Health Give Your Heart a Little TLC Figuring Out Fat Aim for a Healthy Weight Part 1 Aim for a Healthy Weight Part 2 Time to be Active You Can Quit Smoking Aspirin Take with Caution Heart Healthy is a Family Affair A Change of Heart

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Front Physiol 8:1130 Fetterman JL, Weisbrod RM, Feng B, Bastin R, Tuttle ST, Holbrook M et al (2018) Flavorings in tobacco products induce endothelial cell dysfunction