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Lung exposure to fine particulate matter, such as monosodium urate crystals, asbestos, and crystalline silica, results in persistent inflammation, mediated primarily by the NLRP3 inflammasome [72]

[DOI] [PMC free article] [PubMed] [Google Scholar] Zwart R, Carbone AL, Moroni M, Bermudez I, Mogg AJ, Folly EA, Broad LM, Williams AC, Zhang D, Ding C, Heinz BA, Sher E, 2008

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The fact that the FDA has been imprecise about every aspect of this test (see section 6 above) does not make it any less of a standard