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When tobacco is kept in the cheek or under the lip for long periods, the soft tissues are continuously soaked in toxins, leading to a condition called Oral Submucous Fibrosis (OSMF), a precursor to cancer

Our genetics-based findings support and extend the observational literature identifying tobacco smoking as a risk factor for respiratory infection and diseases 9,25,26 , and add to the recent MR literature identifying potential causal links of smoking with reduced lung function 36 , lung cancer 37 , and increased mortality due to respiratory disease 38

J., & Neymark, A

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