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Furthermore, around 60% ( n = 610) of them agreed that the E-cig can be a gateway for conventional tobacco smoking, and it might lead to smoking addiction ( n = 545, 55.4%)

An activity-dependent decrease in the hyperpolarizing Cl gradient decreases GABAergic inhibition and unmasks an outward flux of HCO 3 ions through GABA A Rs, resulting in neuronal depolarization/excitation (Bormann et al., 1987

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