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However, there are several areas of study which point to the role of pathogens and modulation of the immune response in the diseases caused by smoking: The World Health Organization estimates that tobacco caused 5.4 million deaths in 2004 6) and 100 million deaths over the course of the 20th century

For their research, the authors recruited 1,128 people who smoke cigarettes every day or intermittently, along with people who previously smoked