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Later, using a low dose of bleomycin (10ug/mouse daily), the authors found that while wild-type C57BL/6J mice did not show signs of fibrosis at that dose, Mc1r e/e mice, deficient for MC 1 receptor on a C57BL/6J background, displayed obvious signs of fibrosis like increased skin thickness, collagen expression and levels of chemoattractant protein MCP-1, suggesting that the deficiency in Mc1r increases the susceptibility to develop bleomycin-induced fibrosis (194)

DOI: 10.1016/0304-3835(95)03808-A 63

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