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There is a plausible rationale for zinc as supplementation to improve insulin resistance, lipid metabolism and hyperandrogenism in PCOS animals and patients ( Zinc is necessary for many physiological functions including insulin production, storage, and action

DPP-4 inhibitors, such as diprotin A, vildagliptin, and evogliptin tartrate, exhibit analgesic effects in rat models of carrageenan-induced sub-chronic inflammatory pain, as well as acute and tonic pain induced by CFA and formalin [36, 37]

This proliferative effect is likely mediated by IL-6

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Annals of Nutrition and Metabolism, 66 (Suppl