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Both intrinsic factors, properties arising in the malignant cells, such as MYC amplification, PIK3CA , and TP53 mutations, and extrinsic factors, metabolic stresses imposed by the microenvironment, such as hypoxia, oxidative stress, acidosis, contribute to different metabolic programming phenotypes in metastatic breast cancer

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Wen, S., et al., Complementary Cholesterol-Lowering Response of a Phytosterol/-Lipoic Acid Combination in Obese Zucker Rats

GSTs are involved in the main detoxification route of AFB1- exo -8,9-epoxide by catalyzing the conjugation of AFB1- exo -8,9-epoxide to endogenous GSH

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