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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for type 2 diabetes management but now also licensed for weight management

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As mentioned previously, the A1 astrocyte phenotype, induced by microgliaderived IL1, TNF, and C1q, loses its neuroprotective functions and secretes neurotoxic and proinflammatory mediators that exacerbate neuronal damage

[1] [2] These results represent a degree of weight reduction not previously observed with any pharmacological agent in a trial of this duration, though Phase 3 data are required before firm conclusions can be drawn

Emgality (galcanezumab) binds directly to the CGRP ligand the protein itselfneutralizing it before it can reach and activate the receptor